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Antiseptic chewing gum reduces SARS-CoV-2 viral load in exhaled air


Extreme acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of the pandemic coronavirus 2019 (COVID-19), is primarily transmitted by aerosols or droplets. These droplets are produced when an individual contaminated with SARS-CoV-2 talks, sneezes, or coughs.

Study: Reducing the SARS-CoV-2 viral load in exhaled air by chewing antiseptic gum: a pilot trial.  Image credit: Billion Photos /

Analysis: Lowering the SARS-CoV-2 viral load in exhaled air by chewing antiseptic gum: a pilot trial. Picture credit score: Billion Pictures /


The oral cavity performs an essential position within the transmission of SARS-CoV-2, as saliva is a potent route of transmission of COVID-19. Apparently, viral load within the oral cavity is expounded to illness severity. As a precaution, the usage of an antiseptic mouthwash has been advisable to scale back the oral viral load.

It’s thought that in comparison with mouthwashes, gum and lozenges containing antiseptic compounds are simpler to make use of. These merchandise could be stored within the oral cavity for a very long time, the place they’ll slowly and constantly launch the lively substances. Thus far, a number of pure compounds have antiseptic properties, which could possibly be used to develop antiviral lozenges or gum.

Just lately an infection research to find out the effectiveness of antiviral gum in lowering the oral viral load in exhaled air of COVID-19 sufferers.

About analysis

Cyclic cut-off (Ct) values ​​obtained from polymerase chain response (PCR) evaluation assist assess the viral load in exhaled air of sufferers contaminated with SARS-CoV-2. Viral load was measured earlier than and after the usage of antiseptic gum at totally different time factors.

The gum used on this research is commercially out there and incorporates important oils of cinnamon, lemon, and mint, in addition to extracts of ginger, ginseng, quercetin, and sperm.

This pilot research was performed on the IKF Heart for Respiratory Illnesses Medical Analysis, Frankfurt, Germany. The research group included individuals who examined constructive for COVID-19 and had been over 18 years of age.

Exhaled air from all individuals was recorded. Throughout this course of, after being maximally impressed, they had been requested to exhale forcefully via their mouths right into a filter-paper container. The filter papers had been evaluated via PCR to estimate the Ct worth.

Exhaled air samples had been collected at totally different time intervals together with earlier than and after 15 min of antiseptic gum use. Further samples had been collected 30, 45, 60, 90 and 120 min after first pattern assortment.

Analysis outcomes

A complete of 9 symptomatic COVID-19 sufferers participated on this pilot trial. Molecular sequencing revealed that 4 sufferers had been contaminated with the ancestral pressure of SARS-CoV-2, 3 had been of the Alpha variant, and a pair of had been of the Delta variant.

In contrast with the Ct worth obtained earlier than chewing gum, an growing pattern was noticed in all individuals. The imply distinction in Ct values ​​earlier than antiretroviral gum chewing and 15 min after chewing gum was 3.8.

50% discount in viral load per enhance in Ct worth. Primarily based on a rise within the Ct worth, a lower within the viral load in exhaled air was noticed for as much as 120 min. After two hours of chewing antiseptic gum, the viral load decreased from 84% to 93%.

Oral viral load assessed by measuring the Ct worth of exhaled air from a COVID-19 affected person helped decide the extent of an infection. Earlier than in vitro Research have strongly proven the antiviral results of lively substances, similar to ginger extract, cinnamon oil, sperm, peppermint oil, citrus oils, quercetin, and ginseng, current within the sweet. Antiviral rubber.

Studying Limits

A serious limitation of this research is the small variety of individuals. Moreover, the effectiveness of chewing gum in lowering viral load has been evaluated in opposition to three kinds of SAR-CoV-2 variants, whereas many different SARS-CoV-2 variants have emerged.

The current pilot research was performed previous to the emergence of the Omicron variant in Germany, which is presently the predominant circulating pressure and incorporates quite a few genetic mutations.


The numerous discount in viral load after 120 minutes of chewing antiseptic gum signifies a robust antiviral impact in opposition to SARS-CoV-2. It is very important perceive whether or not the lively substances within the gum are accountable for the diminished viral load or if elevated salivation dilutes or reduces the viral load.

Nevertheless, the authors suspect that the lively substances, as a substitute of accelerating saliva manufacturing, scale back the oral viral load. Sooner or later, massive placebo-controlled medical trials are wanted to verify the present research’s findings.

Try the journal:

  • Pfab, F., Buelow-Johansen, B., Alber, D. et al. (2022) Discount of the SARS-CoV-2 viral load in exhaled air by chewing antiseptic gum: a pilot trial. an infection. doi: 10.1007 / s15010-022-01944-2


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